Gut microbiome modulates Drosophila aggression through octopamine signaling
نویسندگان
چکیده
منابع مشابه
Fly Fighting: Octopamine Modulates Aggression
The genetics and neurobiology of Drosophila aggression are still poorly understood. A new study using an automated method to analyze one component of male fly aggression has shown that the biogenic amine octopamine plays a role in the modulation of aggressive behavior.
متن کاملRegulation of aggression by obesity-linked genes TfAP-2 and Twz through octopamine signaling in Drosophila.
In Drosophila, the monoamine octopamine, through mechanisms that are not completely understood, regulates both aggression and mating behavior. Interestingly, our study demonstrates that the Drosophila obesity-linked homologs Transcription factor AP-2 (TfAP-2; TFAP2B in humans) and Tiwaz (Twz; KCTD15 in humans) interact to modify male behavior by controlling the expression of Tyramine β-hydroxyl...
متن کاملOctopamine in Male Aggression of Drosophila
BACKGROUND In mammals and humans, noradrenaline is a key modulator of aggression. Octopamine, a closely related biogenic amine, has been proposed to have a similar function in arthropods. However, the effect of octopamine on aggressive behavior is little understood. RESULTS An automated video analysis of aggression in male Drosophila has been developed, rendering aggression accessible to high...
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UNLABELLED Recent studies have shown that individuals with colorectal cancer have an altered gut microbiome compared to healthy controls. It remains unclear whether these differences are a response to tumorigenesis or actively drive tumorigenesis. To determine the role of the gut microbiome in the development of colorectal cancer, we characterized the gut microbiome in a murine model of inflamm...
متن کاملRegulation of aggression by obesity - linked genes TfAP - 2 and Twz through octopamine signalling in Drosophila
In Drosophila the monoamine octopamine, through mechanisms that are not completely resolved, regulates both aggression and mating behaviour. Interestingly, our study demonstrates that the Drosophila obesity-linked homologues Transcription factor AP-2 (TfAP-2, TFAP2B in humans) and Tiwaz (Twz, KCTD15 in humans) interact to modify male behaviour by controlling the expression of Tyramine -hydroxy...
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ژورنال
عنوان ژورنال: Nature Communications
سال: 2021
ISSN: 2041-1723
DOI: 10.1038/s41467-021-23041-y